Labels:text | screenshot | black and white | black | font | document OCR: neoplastic Bioactive substances may be produced b utocrine cells to act on the same neoplastic cells ( d that effects). The hypothesis has been propos owth cancer cells have the ability to produce g factors and to stimulate tumorigenesis b ism is nowresponding to these factors. This mecha sm of known as the autocrine growth mechan referred to cancer cells: factors responsible for it are rs such as as autocrine growth factors. Growth fact ing growthplatelet-derived growth factor, transform factor 1 L-2) and factor a (TGF-c) and insulin-like growth (IGF-I), cytokines such as interleukin-2 ( es with interleukin-6 (IL-6), and peptide hormo 1 as GRP, activity to stimulate cellular growth, suc tors in a are now regarded as autocrine growth fa variety of cancer cell lines.